A single mutation in the e2 glycoprotein of hepatitis c virus broadens the claudin specificity for its infection

HIGHLIGHTS

• who: Yoshitaka Shirasago from the DepartmentJapanOsaka University have published the Article: A single mutation in the E2 glycoprotein of hepatitis C virus broadens the claudin specificity for its infection, in the Journal: Scientific Reports Scientific Reports of 28/Dec/2021
• what: The authors repeatedly passaged HCV-JFH1-tau, which resultantly showed infectivity on CLDN1-defective S7-A cells (Fig 1).
• how: These results indicated that HCV-JFH1-tau Lot B1 could infect cells without using CLDN1.

SUMMARY

Previously, the authors demonstrated that the HCV-JFH1-tau substrain having K74T . . .

 



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