HIGHLIGHTS
- who: Matthew R. Volpe from the (UNIVERSITY) have published the article: A small molecule inhibitor prevents gut bacterial genotoxin production, in the Journal: (JOURNAL) of 19/08/2022
- what: The authors report small_molecule boronic acid inhibitors of colibactin biosynthesis. Using biochemical assays and crystallography, the authors show that they engage the ClbP binding pocket, forming a covalent_bond with the catalytic serine. The authors show that inhibition of ClbP using these compounds abrogates colibactin production in pks+ E. coli and pks+ communities. The authors show that these compounds can also inhibit closely related peptidases found in . . .
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