A stable cyclized antimicrobial peptide derived from ll-37 with host immunomodulatory effects and activity against uropathogens

HIGHLIGHTS

  • who: John Kerr White from the Department of Microbiology, Tumor and Cell Biology, Division of Clinical Microbiology, Karolinska University have published the paper: A stable cyclized antimicrobial peptide derived from LL-37 with host immunomodulatory effects and activity against uropathogens, in the Journal: (JOURNAL)
  • what: The authors demonstrate the potential of the synthetic peptide designed by dimerization and backbone cyclization of the shortest antimicrobial region of human cathelicidin LL-37. is active against clinical and type strains of common uropathogens Escherichia coli Klebsiella pneumoniae and Pseudomonas aeruginosa at concentrations substantially below cellular cytotoxic levels and . . .

     

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