A structural comparison of sars-cov-2 main protease and animal coronaviral main protease reveals species-specific ligand binding and dimerization mechanism

HIGHLIGHTS

  • who: Chien-Yi Ho et al. from the Department of Biomedical Imaging and Radiological Science, China Medical University have published the Article: A Structural Comparison of SARS-CoV-2 Main Protease and Animal Coronaviral Main Protease Reveals Species-Specific Ligand Binding and Dimerization Mechanism, in the Journal: (JOURNAL) of 18/04/2022
  • what: To overcome this problem the authors focused on the main protease (Mpro ) which is an evolutionary conserved viral protein among different coronaviruses. The dimerization interface also influences the catalytic efficiency of CoV Mpro Conclusively the structural information of this study provides mechanistic . . .

     

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