A substrate binding model for the keops trna modifying complex

HIGHLIGHTS

• who: Jonah Beenstock from the Sinai Hospital University of have published the research: A substrate binding model for the KEOPS tRNA modifying complex, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors show that the recruited tRNA is engaged through an extended binding surface, which involves all four core KEOPS subunits, that is remarkably complementary in shape to that of the tRNA. Based on the mechanistic findings, the authors propose the following model of the KEOPS t6A catalytic cycle (Fig 7g): Step 1: Cgi121 can form a complex with tRNA independent of other KEOPS . . .
  

   

  

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