HIGHLIGHTS
SUMMARY
| https://doi.org/10.1038/s41467-022-30776-9 S ince the 1950s with the first ultrastructural characterization of the synapse in the central nervous system1 a wide variety of synapse types has been described based on morphological criteria2. The archetypal synapse type is the so-called asymmetric excitatory synapse on dendritic spines1, which represent the vast majority of synapses (~80%). Its ultrastructure is easily identifiable in the tissue by the presence of a postsynaptic density and a dense cluster of synaptic vesicles, and it has been extensively studied in_vitro using primary neuronal cultures3 . . .
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