A synopsis of current theories on drug-induced nephrotoxicity

HIGHLIGHTS

SUMMARY

    Kidneys carry out a lot of integrated functions aimed at maintaining the homeostasis of the body, including: the control of the composition and volume of body fluids; electrolytes and acid-base balance; the long-term regulation of blood pressure in a sodium-dependent manner; and the synthesis and secretion of several hormones (e_g, renin, eicosanoids, erythropoietin, and 1,25-dihydroxyvitamin D3). Some of the drug-induced kidney injuries distinguished by Bartoli are consistent with those reported by Awdishu and Mehta, e_g, crystalline nephropathy or the direct toxic effects of drugs on tubular epithelial_cells (Bartoli . . .

     

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