HIGHLIGHTS
- who: Lotfi Slim from the (UNIVERSITY) have published the paper: A systematic analysis of gene-gene interaction in multiple sclerosis, in the Journal: (JOURNAL)
- what: The authors propose a pipeline to that effect which the authors illustrate by investigating a multiple sclerosis GWAS dataset from the Wellcome Trust Case Control Consortium 2 through 19 disease maps from the MetaCore pathway database. The authors report 4 epistatic gene pairs involving missense variants and 25 gene pairs with a deleterious epistatic effect mediated by eQTLs. The study showcases the ability of EpiGWAS to uncover biologically interpretable epistatic . . .
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