A systematic study on the optimal nucleotide analogue concentration and rate limiting nucleotide of the sars-cov-2 rna-dependent rna polymerase

HIGHLIGHTS

• who: Hasan Vatandaslar from the Institute of Molecular Health Sciences, Department of Biology, ETH Zurich, Zurich, Switzerland have published the paper: A Systematic Study on the Optimal Nucleotide Analogue Concentration and Rate Limiting Nucleotide of the SARS-CoV-2 RNA-Dependent RNA Polymerase, in the Journal: (JOURNAL) of 23/07/2022
• what: The authors show that SARS-CoV-2 RdRp inhibition efficiency of remdesivir and cordycepin two common adenosine analogs is influenced by endogenous adenosine level and that the current clinically approved concentrations for COVID-19 treatment are suboptimal for effective RdRp inhibition. As the . . .
  

   

  

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