A systems biology approach to dynamic modeling and inter-subject variability of statin pharmacokinetics in human hepatocytes

HIGHLIGHTS

• who: Joachim Bucher et al. from the Tissue samples from human liver resections were obtained from patients undergoing partial hepatectomyExperimental procedures were performed according to the guidelines of the charitable state-controlled foundation HTCR (Human Tissue and Cell Research) Regensburg, Germany, and the institutional guidelines for liver resections of tumor patients with primary or secondary liver tumors, Technical University Munich, MRI, Munich, Germany. The use of human hepatocytes for research purposes was approved by the local ethics committees of the Ludwig-Maximilians-University of Munich [36] and the Charité, Humboldt University Berlin [37], Germany, and written informed . . .
  

   

  

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