A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis

HIGHLIGHTS

• who: Lohith Madireddy from the replication and reached genome-wide significant in the final combined analysis (GW), those that showed statistically significant evidence of replication but did not reach genomewide significance in the final combined analysis (SR) and those failing to show statistically significant evidence of replication (NR)For each cell type, the number of nodes and edges of each subnetwork and that of its largest connected component were computed. The statistical significances were computed by comparison against a background distribution of, networks of equal size sampled randomly from the same PPI. Cell-specific transcriptomes. This work . . .
  

   

  

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