A tailored tetravalent peptide displays dual functions to inhibit amyloid β production and aggregation

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  • who: Waka Sato from the Graduate School Doshisha University, Kyoto, Japan have published the Article: A tailored tetravalent peptide displays dual functions to inhibit amyloid u03b2 production and aggregation, in the Journal: (JOURNAL) of 17/07/2022
  • how: The authors examined the protective effect of on the cytotoxic activity of prefibrillar aggregates using the Neuro-2a neuronal cell line. For these experiments to increase stability of in mice the authors used protease-resistant Nterminal acetylated form of which shows similar inhibitory effect on production in 7WD10 cells (Supplementary Fig 8). The following antibodies were obtained . . .

     

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