A terpene nucleoside from tuberculosis induces lysosomal lipid storage in foamy macrophages

HIGHLIGHTS

• who: Melissa Bedard et al. from the DivisionUniversity Medical, Suita, Japan have published the Article: A terpene nucleoside from tuberculosis induces lysosomal lipid storage in foamy macrophages, in the Journal: (JOURNAL)
• what: The authors show that a terpenyl nucleoside shed from Mycobacterium tuberculosis 1-tuberculosinyladenosine (1-TbAd) caused lysosomal maturation arrest and autophagy blockade leading to lipid storage in M1 macrophages. Instead, the authors propose a simple model, in which an antacid raises the lysosomal pH, leading to pleiotropic inactivation of lysosomal hydrolases.
• how: Next the authors compared 1-TbAd activity with chloroquine . . .
  

   

  

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