A therapeutic target for ckd: activin a facilitates tgfβ1 profibrotic signaling

HIGHLIGHTS

• who: Asfia Soomro from the Division of Nephrology, McMaster University, Hamilton, Canada have published the Article: A therapeutic target for CKD: activin A facilitates TGFu03b21 profibrotic signaling, in the Journal: (JOURNAL)
• what: The authors show that actA is required for longer-term TGFu03b21-induced fibrotic responses at least in part through regulation of both Smad3 and MRTF-A signaling. (Fig 8), the authors show that actA regulates TGFu03b21 canonical (Smad3) and noncanonical (MRTF-A) signaling to enable its longer-term fibrotic effects both in_vitro and in_vivo.
• how: For this the authors used mice . . .
  

   

  

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