A trans locus causes a ribosomopathy in hypertrophic hearts that affects mrna translation in a protein length-dependent fashion

HIGHLIGHTS

  • who: Franziska Witte from the Berlin, Germany have published the research work: A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion, in the Journal: (JOURNAL)
  • what: The authors investigate the influence of such distant loci on the of mRNA translation and define their contribution to the development of complex disease phenotypes within a of lines. Depending on the factor mutated a pre-existing negative correlation between protein length and translation rates could either be enhanced or reduced which the authors propose to result from mRNA . . .

     

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