A truncated and catalytically inactive isoform of kdm5b histone demethylase accumulates in breast cancer cells and regulates h3k4 tri-methylation and gene expression

HIGHLIGHTS

• who: Elena Di Nisio from the Cell cultures and extracts The human breast cancer cell lines MCF7, T D, and MDA-MB-231, and the human melanoma SK-, cell line were a gift from DrLucia Gabriele (Istituto Superiore di Sanitu00e0, Rome, Italy). Cells were cultured at , u00b0C in a, % , atmosphere for no more than, in vitro passages. The , cells and other T D cells were obtained from the MRC-PPU, University of Dundee (Scotland, UK). The MCF A, MDA-MB-415, MDA-MB-453, SKBR3, MDA-MB-436, MDA-MB-468, SUM-149-PT, and , were obtained . . .
  

   

  

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