HIGHLIGHTS
SUMMARY
Concurrently, protrusions are inhibited in other parts of the cell ("global inhibition") through long-range diffusion of chemical factors (Franca-Koh and Devreotes, 2004) or global mechanical tension (Diz-Muñoz et_al, 2016; Houk et_al, 2012), establishing cell polarity towards the gradient direction. In cells moving in a mesenchymal-like fashion, like fibroblasts, Arp2/3 was found to be dispensable for locomotion per se, but important for coordinating optimal adhesions with the substrate (Wu et_al, 2012; Case and Waterman, 2015). In amoeboid cells, such as leukocytes, which can move in the absence of dedicated . . .
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