A unified scheme for initiation and conformational adaptation of human apolipoprotein e n-terminal domain upon lipoprotein binding and for receptor binding activity*

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• who: Arun Sivashanmugam from the Arun Sivashanmugam and Jianjun Wang, From the Department of Biochemistry and Molecular Biology, School of Medicine, Wayne State University, Detroit, Michigan , We report here a high-resolution NMR structure of the complete receptor-binding domain of human apolipoprotein , (apoE3-NT)Similar to the crystal structure of apoE-NT, the NMR structure displayed an elongated four-helix bundle. However, additional unique structural features were also observed. The segments in the N and C termini, which were missing in the crystal structure, formed ␣-helices having extensive tertiary contacts with the bundle, which oriented these . . .
  

   

  

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