A versatile, compartmentalised gut-on-a-chip system for pharmacological and toxicological analyses

HIGHLIGHTS

  • who: Pim de Haan from the University of have published the article: A versatile, compartmentalised gut-on-a-chip system for pharmacological and toxicological analyses, in the Journal: Scientific Reports Scientific Reports
  • what: A control experiment was conducted to examine the effect of digestive juices (chyme) on the translocation of omeprazole in a static transwell (Fig S3, SI).
  • how: The authors further challenged the system by including microfluidic digestion-on-a-chip (Fig 1a) allowing pre-treatment of samples with digestive juices before studying translocation through a model of the gut wall.
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