A viral-fusion-peptide-like molecular switch drives membrane insertion of botulinum neurotoxin a1

HIGHLIGHTS

• who: Kwok-ho Lam from the University of have published the research work: A viral-fusion-peptide-like molecular switch drives membrane insertion of botulinum neurotoxin A1, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The studies demonstrate that BoNT/A1 contains a molecular switch that regulates channel formation and LC delivery, so it only happens in the right cellular location at the right time.
• how: This result is consistent with the structural analysis that suggested F658E may destabilize the acidic pH conformation but does not directly affect the neutral pH conformation (Fig . . .
  

   

  

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