Aaa⠋+⠋atpase thorase inhibits mtor signaling through the disassembly of the mtor complex 1

HIGHLIGHTS

• who: George K. E. Umanah from the Cell Culture RagAGTP/GTP mouse embryonic fibroblasts were a kind gift from DrAlejo Efeyan (CNIO, Spain have published the research: AAAu280b+u280bATPase Thorase inhibits mTOR signaling through the disassembly of the mTOR complex 1, in the Journal: (JOURNAL) of 14/04/2022
• what: The authors show that the AAA + ATPase Thorase directly binds mTOR, thereby orchestrating the disassembly and inactivation of mTORC1. The authors show that the excess mTORC1 activity in Thorase KO cells and mouse brains can be counteracted with the allosteric mTOR inhibitor, rapamycin. Consistent with . . .
  

   

  

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