Abca1 mutants reveal an interdependency between lipid export function, apoa-i binding activity, and janus kinase 2 activation

HIGHLIGHTS

• who: Ashley M. Vaughan from the DivisionUniversity of have published the research work: ABCA1 mutants reveal an interdependency between lipid export function, apoA-I binding activity, and Janus kinase 2 activation, in the Journal: (JOURNAL)
• what: This study provides additional evidence that the apoA-I-mediated removal of lipids from cells depends Fig 4. This study shows a strong correlation between lipid export, apoA-I binding, and apoA-Idependent JAK2 activation among ABCA1 mutants with varying severities of functional impairment, implying that these different activities are highly interdependent.
• how: Showed that all of . . .
  

   

  

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