Aberrant glial activation and synaptic defects in camkiiα-icre and nestin-cre transgenic mouse models

HIGHLIGHTS

  • who: Alia O. Alia from the Northwestern University Chicago, IL, USA have published the Article: Aberrant glial activation and synaptic defects in CaMKIIu03b1-iCre and nestin-Cre transgenic mouse models, in the Journal: Scientific Reports Scientific Reports
  • what: The authors find that in the absence of floxed alleles, activated microglia and astrocytes proliferated in a distinct pattern throughout the SR and SO hippocampal layers of CaMKIIu03b1-iCre mice compared to WT littermates.
  • how: The authors investigated these effects by utilizing immunofluorescence markers that demonstrate various states of activity reactivity and formation of glial . . .

     

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