HIGHLIGHTS
- who: Iosif Papafragkos and colleagues from the City of Hope, United States Nagoya City University, Japan have published the paper: Ablation of NLRP3 inflammasome rewires MDSC function and promotes tumor regression, in the Journal: (JOURNAL)
- what: Specifically, the authors report a phenotypic, transcriptomic and Frontiers in Immunology frontiersin.org 10.3389/fimmu.2022.889075 A B C D Pharmacologic inhibition of NLRP3 attenuates tumor growth and re-programs the MDSC compartment.
- how: For survival analysis the authors used the bottom and top 33% of patients with either NLRP3 expression or NLRP3 inflammasome module . . .
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