Ablation of trpc3 disrupts ca2+ signaling in salivary ductal cells and promotes sialolithiasis

HIGHLIGHTS

• who: Bok-Eum Choi from the Calcium Signaling LaboratoryThe Catholic University of have published the research: Ablation of TRPC3 disrupts Ca2+ signaling in salivary ductal cells and promotes sialolithiasis, in the Journal: Scientific Reports Scientific Reports
• what: This study has been performed under ARRIVE guidelines.

SUMMARY

Patched WT_cells revealed an outwardly rectifying current at -80 mV, which is characteristic of a TRPC3 activated ­current26. In both instances, prominent calcification was observed at the ductal site of the SMG that the TRPC3 KO mice could be a translational candidate for salivary stone . . .

 



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