Abrogation of cellular senescence induced by temozolomide in glioblastoma cells: search for senolytics

HIGHLIGHTS

• who: Lea Beltzig et al. from the Institute of Toxicology, University Medical Center Mainz, Obere Zahlbacher Str67, Mainz, Germany have published the paper: Abrogation of Cellular Senescence Induced by Temozolomide in Glioblastoma Cells: Search for Senolytics, in the Journal: Cells 2022, 11, 2588. of /2022/
• what: In the experiments , the senescent population was obtained by TMZ treatment followed by 8-10 d recovery, which yielded >80% senescent cells (for time course see ref ).
• how: Several proteins involved in the DNA damage response (DDR) ATM ATR Chk1/2 p53 p21 NF-KB Rad51 PARP . . .
  

   

  

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