Abrogation of notch signaling in embryonic tecs impacts postnatal mtec homeostasis and thymic involution

HIGHLIGHTS

• who: Marí from the Rudjer Boskovic Institute, Croatia United States Sapienza University of Rome, Italy have published the article: Abrogation of Notch Signaling in Embryonic TECs Impacts Postnatal mTEC Homeostasis and Thymic Involution, in the Journal: (JOURNAL)
• what: The authors show that, after mTEC numbers are normalized, abrogation of Notch signaling in mutant mice results in a further age-dependent dramatic loss of mTECs.
• how: The authors made use of an in_vivo genetic model of Foxn1-controlled conditional inactivation of Notch signaling in murine epithelial_cells including TECs and reveal that lack of . . .
  

   

  

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