HIGHLIGHTS
- who: Sepideh Kiani Shabestari from the of Neurobiology and Behavior, UC Irvine, Irvine, CA, USA University of have published the paper: Absence of microglia promotes diverse pathologies and early lethality in Alzheimer`s disease mice, in the Journal: (JOURNAL) of June/14,/2022
- what: Given the marked effects of FIRE deletion on CAA and the association of transplanted microglia with brain vasculature, the authors focused the attention on endothelial cells (ENDs). Taken together, this study provides intriguing evidence that microglia are intimately involved in the development of multiple AD-associated pathologies.
SUMMARY
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