HIGHLIGHTS
- who: Wai Cheung Chan from the (UNIVERSITY) have published the research work: Accelerating inhibitor discovery for deubiquitinating enzymes, in the Journal: (JOURNAL) of 22/Dec/2021
- future: The high -content primary screen in which the authors profiled 178 compounds against 56 DUBs revealed multi-parameter SAR trends which will accelerate future studies.
SUMMARY
Pairing the library with activity-based protein profiling as a high-density primary screen, the authors identify selective hits against 23 endogenous DUBs spanning four subfamilies. Efforts to demonstrate the clinical benefit of DUB inhibition have been hampered . . .
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