HIGHLIGHTS
- who: Harikrishnan k from the First Hospital of Jilin University, Changchun, China have published the research: Accepted Manuscript, in the Journal: (JOURNAL)
SUMMARY
Robust xenogeneic immune_responses impede pig organ survival after transplantation in non-human primates (NHPs). Incompatibility of immune and coagulation regulatory_genes between species also leads to pig organ xenotransplantation failure. The Alabama team used a 10-GE pigs, in which human complement regulatory_genes (hCD55, hCD46), d coagulation regulatory_genes (hTBM, hEPCR), macrophage function regulatory_gene pt e (hCD47), anti-inflammatory gene (hHO1) were incorporated. There were no human IgM, IgG, C4d complement deposition . . .
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