Accessible light-controlled knockdown of cell-free protein synthesis using phosphorothioate-caged antisense oligonucleotides

HIGHLIGHTS

• who: Denis Hartmann from the University of have published the research: Accessible light-controlled knockdown of cell-free protein synthesis using phosphorothioate-caged antisense oligonucleotides, in the Journal: (JOURNAL) of 20/01/2023
• what: The authors report a mild one-step method to photocage the backbone of ASOs at defined positions using phosphorothioate (PS) backbone modifications in combination with the commerciallyavailable halogenated photocage-precursor 2-nitroveratryl bromide (Fig 1).
• future: Future work to address these issues will include ON modification using water-soluble and more redshifted analogues of the photocages expanding and facilitating . . .
  

   

  

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