Accounting for the clustering and nesting effects verifies most conclusions. corrected analysis of: “randomized nutrient bar supplementation improves exercise-associated changes in plasma metabolome in adolescents and adult family members at cardiometabolic risk”

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SUMMARY

The authors present a valid statistical model that accounts for clustering and nesting effects within the context of other methodologic choices Ignoring clustering and nesting effects in group randomized trial results in unsubstantiated conclusions made by the original authors. In the case of plasma ceramides, sphingolipid bases, and amino_acids, however, adolescents and adults were analyzed together but the clustering effect of households and the nesting effect that arises from the hierarchical structure of the data were not considered in the statistical analyses. The inconsistency in the analysis of different outcomes aside, the authors outline . . .

 



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