Accurate de novo design of membrane-traversing macrocycles

HIGHLIGHTS

• who: Gaurav Bhardwaj from the Institut University of Washington, Seattle, WA, USA have published the research work: Accurate de novo design of membrane-traversing macrocycles, in the Journal: (JOURNAL) of September/15,/2022
• what: With such control the authors show that membrane permeability can be systematically achieved by ensuring all amide (NH) groups are engaged internal hydrogen bonding interactions. Because Caco-2 assays are resource intensive, the authors focused on testing the largersized 8 residue macrocycles and did not carry out this assay on the 6 and 7 residue macrocycles. While the authors focus here . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or E-mail:

  If you don't have an account, you can create one here.