Accurate identification of subclones in tumor genomes

HIGHLIGHTS

• who: Navid Ahmadinejad et al. from the College of Health Solutions, Arizona State University, Phoenix, AZ, USA have published the research: Accurate Identification of Subclones in Tumor Genomes, in the Journal: (JOURNAL)
• what: Along the root-to-leaves path, the authors examine the clade at each branching point and test the null hypothesis that all VAFs in this clade are drawn from the same beta distribution. Using one-sample one-sided t-test, the authors evaluate if var(v) u2264 var(x). During tree partitioning, the authors evaluate if var(vs ) u2264 var(xs ) for . . .
  

   

  

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