Acetylation-specific interference by anti-histone h3k9ac intrabody results in precise modulation of gene expression

HIGHLIGHTS

  • who: Simonetta Lisi and collaborators from the European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa have published the paper: Acetylation-Specific Interference by Anti-Histone H3K9ac Intrabody Results in Precise Modulation of Gene Expression, in the Journal: (JOURNAL)
  • what: To this aim, in this paper, the authors exploited intracellularly expressed antibody domains (intrabodies) and the recently developed P.I.S.A (Post-translational Intracellular Silencing Antibody) technology for the in_vivo selection of intrabodies that specifically bind PTM-epitopes on the . . .

     

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