Acid sphingomyelinase deactivation post-ischemia promotes brain angiogenesis and remodeling by small extracellular vesicles

HIGHLIGHTS

• who: Ayan Mohamud Yusuf from the Hufelandstr55, Essen, Germany University Hospital Essen, Essen, Germany have published the research: Acid sphingomyelinase deactivation post-ischemia promotes brain angiogenesis and remodeling by small extracellular vesicles, in the Journal: (JOURNAL)
• what: The authors examined effects of Asm inhibitors, many of which are clinically used as antidepressants, on cerebral angiogenesis, brain tissue remodeling and functional recovery after focal cerebral ischemia/reperfusion (I/R). Expanding these previous findings the authors propose that intraluminal membrane budding may be determined by the balance of sphingomyelinase activities on both membrane leaflets and that reduced . . .
  

   

  

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