HIGHLIGHTS
SUMMARY
High acetate levels can also be seen as an indicator of fatty_acid synthesis, as the authors saw a positive correlation between acetate and fatty_acids. In the omentum, fatty_acid synthesis, fatty_acid oxidation and subsequent ketogenesis are involved in the formation of ascites, thus altering the normal metabolism to a more carcinogenic phenotype. Carnitine plays hereby a critical role as those fatty_acids are transported as acyl-carnitine into the mitochondria, where fatty_acids are oxidized. Adipocytes facilitate the metastasis of OC cells by secreting adipokine (IL-6, IL-8, and MCP-1), and IL-8 is the . . .
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