Acidic extracellular ph induces matrix metalloproteinase-9 expression in mouse metastatic melanoma cells through the phospholipase d-mitogen-activated protein kinase signaling*

HIGHLIGHTS

• who: Yasumasa Kato from the signaling of IL-1␤ and cell to cell contact to induce , expression (44, ), ets is a candidate for another transcription factor that is involved in the acidic pHe signalingAcidic pHe has also been shown to increase the expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase (15), (, ), and VEGF (17, ) in various types of cells. The , promoter contains , and NF␬B sites that are important for its regulation (46), and its induction is driven by p38, ERK1/2, and PLD (47, ). VEGF expression is also induced by p, (49), and expression . . .
  

   

  

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