HIGHLIGHTS
SUMMARY
In turn, metabolic blockers can impair drug-resistance systems of prostate cancer cells and increase the chemosensitivity of prostate tumors, thus reducing the effective doses and side effects of cytostatic drugs. Actually, the authors observed an enhancement of DCX sensitivity and inhibition of drug efflux in PC-3 WT and DU145 WT_cells upon the combined application of DCX/MET. Activation of glycolysis may partly compensate for this effect, whereas the block of OXPHOS and intensified PARP-dependent repair of DCX/MET-induced DNA aberrations collectively account for the high NAD(P) H levels in . . .
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