Acsl4-dependent ferroptosis does not represent a tumor-suppressive mechanism but acsl4 rather promotes liver cancer progression

HIGHLIGHTS

• who: Julia Grube from the Mouse generation and housing To generate hepatocyte-specific Acsl, knockout mice (designated as Acsl4Δhepa), we combined a C BL/, transgenic mouse strain, Alfp-Cre [25], expressing Cre recombinase under control of the mouse albumin promoter regulatory elements and the α-fetoprotein enhancers with a mouse strain carrying floxed alleles of Acsl4, which originated from the European Conditional Mouse Mutagenesis Program (EUCOMM) ES clone EPD0066_2_D Alfp-Cre-negative littermates (Acsl4f/f) served as controls. Animals were housed under specific pathogen-free conditions in the animal facility of University Hospital RWTH Aachen at a . . .
  

   

  

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