Acting on the cftr membrane-spanning domains interface rescues some misfolded mutants

HIGHLIGHTS

• who: Nesrine Baatallah et al. from the CNRS, UMR, Paris, France have published the research: Acting on the CFTR Membrane-Spanning Domains Interface Rescues Some Misfolded Mutants, in the Journal: (JOURNAL)
• what: The authors report on MSD1 L188W, which was identified as a revertant of the folding defect of mutant L206W but not of mutant F508del, when exploring possible binding_sites of pharmaco-chaperones . The authors show that MSD1 contains a second site mutation (or revertant), L188W, which was able to partially rescue L206W and to a lesser extent P67L and E92K, likely favoring the assembly . . .
  

   

  

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