Activated amino acid response pathway generates apatinib resistance by reprograming glutamine metabolism in non-small-cell lung cancer

HIGHLIGHTS

• who: Xiaoshu Zhou from the Animal experiments Human NSCLC , cells were stably transfected with lentiviral vectors encoding shATF4/sh, or empty control lentiviral vectorsThe number of transfected cells were quantitated with a Coulter counter before the , cells (, u00d7 , per mouse) were injected into the BALB/c mice (6-week-old, female). The animal experiments were conducted with the approval of the Institutional Animal Ethics Committee of Huazhong University of Science and Technology. The injection site is subcutaneous at the right flank of the mice and were randomly divided into four groups. Five mice were used in each . . .
  

   

  

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