HIGHLIGHTS
- who: Yuxia Qian from the (UNIVERSITY) have published the research: Activation and signaling mechanism revealed by GPR119-Gs complex structures, in the Journal: (JOURNAL) of 21/04/2022
- what: The authors report the cryo-EM structures of two agonist-bound GPR119-Gs signaling complex and detailed interactions between the agonists and the receptor.
SUMMARY
The authors present the cryo-electron microscopy (cryo-EM) structures of the human GPR119-Gs signaling complexes bound to AR231453 and MBX-2982, two representative agonists reported for GPR119. Both cryo-EM maps of the AR231453- and . . .
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