Activation-free sulfonyl fluoride probes for fragment screening

HIGHLIGHTS

• who: Lu00e1szlu00f3 Petri and colleagues from the Department of Organic Chemistry and Technology, University of Technology and Economics have published the research: Activation-Free Sulfonyl Fluoride Probes for Fragment Screening, in the Journal: Molecules 2023, 3042 of /2023/
• what: The authors report the synthesis and characterization of a small sulfonyl fluoride library that yielded the 3-carboxybenzenesulfonyl fluoride warhead for tagging tractable targets at nucleophilic residues. Based on these results the authors propose that coupling diverse fragments to this warhead would result in a library of sulfonyl fluoride bits (SuFBits) available for screening against protein . . .
  

   

  

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