Activation of adrb2/pka signaling pathway facilitates lipid synthesis in meibocytes, and beta-blocker glaucoma drug impedes pka-induced lipid synthesis by inhibiting adrb2

HIGHLIGHTS

  • who: Ikhyun Jun and colleagues from the The Institute of Vision Research, Department of Ophthalmology, University College of Medicine have published the paper: Activation of ADRB2/PKA Signaling Pathway Facilitates Lipid Synthesis in Meibocytes, and Beta-Blocker Glaucoma Drug Impedes PKA-Induced Lipid Synthesis by Inhibiting ADRB2, in the Journal: (JOURNAL)
  • what: The authors investigated the biological function of the 2-adrenergic receptor (ADRB2)/protein kinase A (PKA) in lipid synthesis and its underlying mechanisms in human meibomian gland epithelial cells (HMGECs). The authors treated HMGECs with forskolin to increase cAMP levels and evaluated CREB . . .

     

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