Activation of piezo1 sensitizes cells to trail-mediated apoptosis through mitochondrial outer membrane permeability

HIGHLIGHTS

• who: Jacob M. Hope from the (UNIVERSITY) have published the research work: Activation of Piezo1 sensitizes cells to TRAIL-mediated apoptosis through mitochondrial outer membrane permeability, in the Journal: (JOURNAL)
• what: The authors examine the mechanism of this TRAIL sensitization with the goal of translating it to static conditions. The experimental results of this study informed a computational model the authors developed from the AlbeckSorger model44.
• future: For future work to conclusively show this Bax expression could be induced in DU145 cells to analyze if it allows for Yoda1-TRAIL sensitization.

 

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