HIGHLIGHTS
- who: A Chatterjee from the DivisionPathology, Park Clinic, Gorky Terrace, Kolkata, India have published the Article: Activation of protein kinase CK2 attenuates FOXO3a functioning in a PML-dependent manner: implications in human prostate cancer, in the Journal: (JOURNAL)
- what: The authors demonstrate that a finely orchestrated signaling concatenation operates, commanded by CK2, causing untimely degradation of PML thereby perpetuating abnormal activity of AKT inside the cell nucleus.
- how: Similar observation is made with reporter assay with p21Cip1 (another FOXO3a controlled gene36) gene promoter also (Supplementary Figure S-5a).
SUMMARY
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