Activation of the adhesion g protein-coupled receptor gpr133 by antibodies targeting its n-terminus

HIGHLIGHTS

• who: Gabriele Stephan from the Gabriele Stephan1, *, Joshua DFrenster1, Ines Liebscher2, and Dimitris G. Placantonakis1, , , * From the Department of Neurosurgery, NYU Grossman School of Medicine, New York, New York, USA have published the research: Activation of the adhesion G protein-coupled receptor GPR133 by antibodies targeting its N-terminus, in the Journal: (JOURNAL) of February/26,/2022
• what: The authors show that treatment of HEK293T_cells overexpressing GPR133 with these antibodies increased cAMP levels in a concentration-dependent manner. The authors demonstrate the antibody-mediated stimulation of WT GPR133, but not the cleavage-deficient H543R mutant . . .
  

   

  

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