Activation of the canonical er stress ire1-xbp1 pathway by insulin regulates glucose and lipid metabolism

HIGHLIGHTS

• who: Jinghua Peng from the Jinghua Peng1, Caolitao Qin1, Balamurugan Ramatchandirin1, Alexia Pearah1, Shaodong Guo2, Mehboob Hussain3, Liqing Yu4, Fredric EWondisford5, and Ling He1, * From the Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA have published the research: Activation of the canonical ER stress IRE1-XBP1 pathway by insulin regulates glucose and lipid metabolism, in the Journal: (JOURNAL)
• what: The authors report that in the fed state, insulin-activated kinase AKT directly phosphorylates inositolrequiring enzyme 1 at S724, which in turn mediates the splicing of XBP1u mRNA, thus favoring the generation . . .
  

   

  

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