Activation of the eif2-atf4 pathway by chronic paracetamol treatment is prevented by dietary supplementationwith cysteine

HIGHLIGHTS

• who: Valu00e9rie Carraro and colleagues from the Universitu00e9 Clermont Auvergne, INRAE, UNH Unitu00e9 de Nutrition Humaine, have published the article: Activation of the eIF2-ATF4 Pathway by Chronic Paracetamol Treatment Is Prevented by Dietary Supplementationwith Cysteine, in the Journal: (JOURNAL) of 17/05/2022
• what: The authors show here that (i) GCN2 is activated by APAP treatment inducing a low plasma concentration of cyst(e)ine and that (ii) this activation is abrogated by the dietary supplementation with Cys. The authors show that chronic treatment with APAP increases NRF2 phosphorylation in the liver along with . . .
  

   

  

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